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RIFINs displayed on malaria-infected erythrocytes bind KIR2DL1 and KIR2DS1

Nature, Published online: 11 June 2025; doi:10.1038/s41586-025-09091-yCertain RIFINs from Plasmodium falciparum can bind to both inhibitory (KIR2DL1) and activating (KIR2DS1) immune receptors on natural killer cells, demonstrating the potential role of activating killer immunoglobulin-like receptors in targeting pathogens and controlling malaria infection.

Jun 11, 2025 - 17:06
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RIFINs displayed on malaria-infected erythrocytes bind KIR2DL1 and KIR2DS1

Nature, Published online: 11 June 2025; doi:10.1038/s41586-025-09091-yCertain RIFINs from Plasmodium falciparum can bind to both inhibitory (KIR2DL1) and activating (KIR2DS1) immune receptors on natural killer cells, demonstrating the potential role of activating killer immunoglobulin-like receptors in targeting pathogens and controlling malaria infection.

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