Mice born of two dads reveal hidden details of mammalian reproduction

Researchers at Shanghai Jiao Tong University have produced fertile adult mice from embryos constructed entirely with male genetic material. Mice carrying only paternal DNA developed into fertile adults following precision editing of seven imprinting control regions, revealing genomic imprinting as a core barrier to uniparental mammalian development.

Jun 25, 2025 - 15:28
 0
Researchers at Shanghai Jiao Tong University have produced fertile adult mice from embryos constructed entirely with male genetic material. Mice carrying only paternal DNA developed into fertile adults following precision editing of seven imprinting control regions, revealing genomic imprinting as a core barrier to uniparental mammalian development.