Mechanism of cytarabine-induced neurotoxicity
Nature, Published online: 25 June 2025; doi:10.1038/s41586-025-09210-9Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas less neurotoxic agents induce single-stranded breaks.
Nature, Published online: 25 June 2025; doi:10.1038/s41586-025-09210-9Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas less neurotoxic agents induce single-stranded breaks.
