Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins | Science

The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split intein–mediated protein splicing, genetic code expansion,...

May 1, 2025 - 19:10
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Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins | Science
The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split intein–mediated protein splicing, genetic code expansion,...