Discovery links RyR1 activation and calcium release to sedative effects of inhalational anesthetics

Since their effects were discovered approximately 180 years ago, inhalational anesthetics have been used for general anesthesia in surgical operations. However, the mechanism of their anesthetic effect has not yet been fully revealed. Previous studies have shown that inhalational anesthetics exert their anesthetic effects by acting on multiple proteins, but the presence of unknown target molecules has also been suggested.