Sleep pressure accumulates in a voltage-gated lipid peroxidation memory
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08734-4Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state of a stably bound NADPH cofactor.
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08734-4Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state of a stably bound NADPH cofactor.
