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Structural dynamics of DNA unwinding by a replicative helicase

Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08766-wCryo-electron microscopy structures of DNA helicases in various conformations provide insight into an ATP-hydrolysis-dependent ‘entropy switch’ that drives unwinding of DNA for replication, with probable conservation across viral and eukaryotic systems.

Mar 19, 2025 - 17:48
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Structural dynamics of DNA unwinding by a replicative helicase

Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08766-wCryo-electron microscopy structures of DNA helicases in various conformations provide insight into an ATP-hydrolysis-dependent ‘entropy switch’ that drives unwinding of DNA for replication, with probable conservation across viral and eukaryotic systems.

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