Decoding the molecular commonality underlying lip hypertrophy in cichlids

Researchers have discovered that the genes related to extracellular matrix (ECM) and the Wnt signaling pathway characterize the independently acquired lip hypertrophy in cichlids of the East African Great Lakes. Through advanced omics-based experiments and comparative histological analyses, they found that hypertrophied lips of cichlids had a larger proteoglycan-rich layer. This study provides vital insights into the evolutionary biology of lip hypertrophy in cichlids of the East African Great Lakes.