Why a standard method overlooks the real reason some antibiotics fail
Nature, Published online: 05 February 2025; doi:10.1038/d41586-025-00348-0Antibiotics show limited effectiveness against Salmonella bacteria in infected mice. Conventional methods of analysing bacterial growth suggest that a small subset of hyper-resilient bacteria is the main cause of this poor efficacy. However, direct monitoring of antibiotic action in real time reveals that such methods are misleading, and that Salmonella resilience is a population-wide trait.
Nature, Published online: 05 February 2025; doi:10.1038/d41586-025-00348-0Antibiotics show limited effectiveness against Salmonella bacteria in infected mice. Conventional methods of analysing bacterial growth suggest that a small subset of hyper-resilient bacteria is the main cause of this poor efficacy. However, direct monitoring of antibiotic action in real time reveals that such methods are misleading, and that Salmonella resilience is a population-wide trait.
