Targeting the SHOC2–RAS interaction in RAS-mutant cancers
Nature, Published online: 07 May 2025; doi:10.1038/s41586-025-08931-1A study of dependencies associated with cancer-causing mutations has identified a small molecule that binds to SHOC2 and inhibits RAS signalling in cells carrying NRAS Q61 mutations, a common oncogenic driver in melanoma.
Nature, Published online: 07 May 2025; doi:10.1038/s41586-025-08931-1A study of dependencies associated with cancer-causing mutations has identified a small molecule that binds to SHOC2 and inhibits RAS signalling in cells carrying NRAS Q61 mutations, a common oncogenic driver in melanoma.
