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Stress dynamically modulates neuronal autophagy to gate depression onset
Nature, Published online: 09 April 2025; doi:10.1038/s41586-025-08807-4Acute stress activates autophagy in the lateral habenula, whereas chronic stress suppresses it, with this autophagy having a causal role in maintaining emotional homeostasis against stress, and its restoration through autophagy enhancers offers a novel antidepressant strategy.
Nature, Published online: 09 April 2025; doi:10.1038/s41586-025-08807-4Acute stress activates autophagy in the lateral habenula, whereas chronic stress suppresses it, with this autophagy having a causal role in maintaining emotional homeostasis against stress, and its restoration through autophagy enhancers offers a novel antidepressant strategy.
