SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08574-8A biochemical system recapitulates the hallmarks of meiotic double-strand break formation, with mouse SPO11 catalysing break formation in the absence of any partners and remaining covalently attached to 5′ broken strands.
Nature, Published online: 19 February 2025; doi:10.1038/s41586-024-08574-8A biochemical system recapitulates the hallmarks of meiotic double-strand break formation, with mouse SPO11 catalysing break formation in the absence of any partners and remaining covalently attached to 5′ broken strands.
