Reverse electron transport drives metabolic changes in obesity
Nature, Published online: 28 May 2025; doi:10.1038/d41586-025-01621-yMitochondria, best known for converting nutrients into energy, also generate superoxide and hydrogen peroxide — redox signalling molecules that become harmful when overproduced. Research reveals that such overproduction is not random, but rather occurs at a specific site in one mitochondrial enzyme, opening the door to targeted therapies for metabolic diseases.
Nature, Published online: 28 May 2025; doi:10.1038/d41586-025-01621-yMitochondria, best known for converting nutrients into energy, also generate superoxide and hydrogen peroxide — redox signalling molecules that become harmful when overproduced. Research reveals that such overproduction is not random, but rather occurs at a specific site in one mitochondrial enzyme, opening the door to targeted therapies for metabolic diseases.
