PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease
Nature, Published online: 07 May 2025; doi:10.1038/s41586-025-08942-yLysosomal phospholipase PLA2G15 was identified as a physiological BMP hydrolase whose activity depends on unique esterification and stereochemistry of BMP and offers a potential therapeutic target for Niemann–Pick disease type C1 and other neurodegenerative conditions.
Nature, Published online: 07 May 2025; doi:10.1038/s41586-025-08942-yLysosomal phospholipase PLA2G15 was identified as a physiological BMP hydrolase whose activity depends on unique esterification and stereochemistry of BMP and offers a potential therapeutic target for Niemann–Pick disease type C1 and other neurodegenerative conditions.
