Peptide bridge enables cofactor channeling in fusion enzyme and cuts NADPH use

Oxidoreductases are key enzymes in biocatalysis, but their dependence on the cofactor nicotinamide adenine dinucleotide (phosphate) (NAD(P)) presents challenges due to its high consumption and associated costs. Improving the cofactor utilization efficiency of these enzymes in biocatalysis is of great significance.

Jun 4, 2025 - 16:52
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Oxidoreductases are key enzymes in biocatalysis, but their dependence on the cofactor nicotinamide adenine dinucleotide (phosphate) (NAD(P)) presents challenges due to its high consumption and associated costs. Improving the cofactor utilization efficiency of these enzymes in biocatalysis is of great significance.