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Loss of colonic fidelity enables multilineage plasticity and metastasis

Nature, Published online: 04 June 2025; doi:10.1038/s41586-025-09125-5The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.

Jun 4, 2025 - 16:21
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Loss of colonic fidelity enables multilineage plasticity and metastasis

Nature, Published online: 04 June 2025; doi:10.1038/s41586-025-09125-5The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.

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