Hidden architecture: Researchers identify new molecular structure at center of chromosomes

Centromeres, specialized regions located at the center of chromosomes, are critical for ensuring proper cell division. During mitosis, centromeres serve as assembly sites for complex protein structures called kinetochores, which connect chromosomes to the spindle apparatus to appropriately distribute genetic material to both daughter cells. Despite their fundamental biological role, the precise molecular architecture of centromeres has remained unclear, with scientists seeking to understand how these regions differ structurally from the rest of the chromosome.