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Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity

Nature, Published online: 21 May 2025; doi:10.1038/s41586-025-08997-xA population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve outcomes.

May 21, 2025 - 17:00
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Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity

Nature, Published online: 21 May 2025; doi:10.1038/s41586-025-08997-xA population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve outcomes.

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