ExIGS bridges microscopy and sequencing to track nuclear abnormalities
Harvard University researchers at the Broad Institute report that expansion in situ genome sequencing (ExIGS) linked nuclear abnormalities to hotspots of aberrant chromatin regulation, potentially eroding cell identity. The findings offer insight into age-related cell failure and showcase the ability of ExIGS to simultaneously sequence DNA and image proteins at nanoscale.
Harvard University researchers at the Broad Institute report that expansion in situ genome sequencing (ExIGS) linked nuclear abnormalities to hotspots of aberrant chromatin regulation, potentially eroding cell identity. The findings offer insight into age-related cell failure and showcase the ability of ExIGS to simultaneously sequence DNA and image proteins at nanoscale.
