Deep learning–guided design of dynamic proteins | Science

Deep learning has advanced the design of static protein structures, but the controlled conformational changes that are hallmarks of natural signaling proteins have remained inaccessible to de novo design. Here, we describe a general deep learning–guided ...

May 22, 2025 - 19:12
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Deep learning–guided design of dynamic proteins | Science
Deep learning has advanced the design of static protein structures, but the controlled conformational changes that are hallmarks of natural signaling proteins have remained inaccessible to de novo design. Here, we describe a general deep learning–guided ...