De novo design of transmembrane fluorescence-activating proteins

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08598-8A study describes the design of de novo ligand-binding transmembrane proteins, demonstrating their specific binding and activation of fluorogenic ligands.

Feb 19, 2025 - 17:19
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De novo design of transmembrane fluorescence-activating proteins

Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08598-8A study describes the design of de novo ligand-binding transmembrane proteins, demonstrating their specific binding and activation of fluorogenic ligands.