Cancer vulnerabilities exposed by finding interactions among DNA repair factors
Nature, Published online: 09 April 2025; doi:10.1038/d41586-025-01049-4A screen of interactions between genes involved in the cell’s response to DNA damage has revealed several previously unreported ‘synthetic lethalities’, in which disrupting a pair of genes, but not either gene alone, causes cell death. The resulting map of genetic interactions could help to identify therapeutic targets for cancer.

Nature, Published online: 09 April 2025; doi:10.1038/d41586-025-01049-4A screen of interactions between genes involved in the cell’s response to DNA damage has revealed several previously unreported ‘synthetic lethalities’, in which disrupting a pair of genes, but not either gene alone, causes cell death. The resulting map of genetic interactions could help to identify therapeutic targets for cancer.