The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08624-9A study reports that the structural maturation of the matrix domain of the Gag protein of HIV-1 is induced by the proteolytic release and binding of the spacer peptide SP2.

Feb 26, 2025 - 18:01
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The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08624-9A study reports that the structural maturation of the matrix domain of the Gag protein of HIV-1 is induced by the proteolytic release and binding of the spacer peptide SP2.