Structural pathway for PI3-kinase regulation by VPS15 in autophagy | Science

The class III phosphatidylinositol-3 kinase complexes I and II (PI3KC3-C1 and PI3KC3-C2) have vital roles in macroautophagy and endosomal maturation, respectively. We elucidated a structural pathway of enzyme activation through cryo–electron microscopy ...

Apr 10, 2025 - 19:12
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Structural pathway for PI3-kinase regulation by VPS15 in autophagy | Science
The class III phosphatidylinositol-3 kinase complexes I and II (PI3KC3-C1 and PI3KC3-C2) have vital roles in macroautophagy and endosomal maturation, respectively. We elucidated a structural pathway of enzyme activation through cryo–electron microscopy ...