Oxidation of retromer complex controls mitochondrial translation

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08756-ySystematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive oxygen species signals.

Mar 26, 2025 - 17:20
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Oxidation of retromer complex controls mitochondrial translation

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08756-ySystematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive oxygen species signals.