New understanding of protein processing could have implications for Alzheimer's and some cancers

Healthy cells are constantly breaking down proteins and building up new ones with the help of enzymes aptly named unfoldases, because they unravel proteins tagged for destruction or recycling. Now, a new electron microscopy study demonstrates how VCP, one such unfoldase, physically interacts with tag removal enzymes, called DUBs.

Jun 5, 2025 - 18:22
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Healthy cells are constantly breaking down proteins and building up new ones with the help of enzymes aptly named unfoldases, because they unravel proteins tagged for destruction or recycling. Now, a new electron microscopy study demonstrates how VCP, one such unfoldase, physically interacts with tag removal enzymes, called DUBs.