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<i>MYC</i> ecDNA promotes intratumour heterogeneity and plasticity in PDAC

Nature, Published online: 12 March 2025; doi:10.1038/s41586-025-08721-9In a model of pancreatic ductal adenocarcinoma, extrachromosomal DNAs are shown to be a source of high-level focal amplification driving MYC heterogeneity and phenotypic adaptation.

Mar 12, 2025 - 18:08
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<i>MYC</i> ecDNA promotes intratumour heterogeneity and plasticity in PDAC

Nature, Published online: 12 March 2025; doi:10.1038/s41586-025-08721-9In a model of pancreatic ductal adenocarcinoma, extrachromosomal DNAs are shown to be a source of high-level focal amplification driving MYC heterogeneity and phenotypic adaptation.

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