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Immune molecule links COVID‑19 with severe inflammatory disorder in children
Nature, Published online: 12 March 2025; doi:10.1038/d41586-025-00735-7The immune molecule TGFβ has been found to weaken immune defences against latent viruses, triggering reactivation of the Epstein–Barr virus. This mechanism links TGFβ release in SARS-CoV-2 infection to multisystem inflammatory syndrome in children, and could inform the development of therapies for managing this serious condition.
Nature, Published online: 12 March 2025; doi:10.1038/d41586-025-00735-7The immune molecule TGFβ has been found to weaken immune defences against latent viruses, triggering reactivation of the Epstein–Barr virus. This mechanism links TGFβ release in SARS-CoV-2 infection to multisystem inflammatory syndrome in children, and could inform the development of therapies for managing this serious condition.
