Molecular brake sheds light on unusual signaling pathway that orchestrates synaptic maturation

Researchers from the lab led by Prof. Joris De Wit (VIB-KU Leuven) have discovered an important clue to how connections between brain cells, known as synapses, mature. These new findings, published in Developmental Cell, demonstrate how two different proteins, GPR158 and PLCXD2, interact to form a specific component in developing synapses—the spine apparatus.

May 20, 2025 - 16:22
 0
Researchers from the lab led by Prof. Joris De Wit (VIB-KU Leuven) have discovered an important clue to how connections between brain cells, known as synapses, mature. These new findings, published in Developmental Cell, demonstrate how two different proteins, GPR158 and PLCXD2, interact to form a specific component in developing synapses—the spine apparatus.