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Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08589-9Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Feb 26, 2025 - 18:01
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Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08589-9Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

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