Deep-tissue transcriptomics and subcellular imaging at high spatial resolution | Science

Limited color channels in fluorescence microscopy have long constrained spatial analysis in biological specimens. We introduce cycle hybridization chain reaction (cycleHCR), a method that integrates multicycle DNA barcoding with HCR to overcome this ...

Apr 17, 2025 - 19:12
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Deep-tissue transcriptomics and subcellular imaging at high spatial resolution | Science
Limited color channels in fluorescence microscopy have long constrained spatial analysis in biological specimens. We introduce cycle hybridization chain reaction (cycleHCR), a method that integrates multicycle DNA barcoding with HCR to overcome this ...