Conformational ensembles reveal the origins of serine protease catalysis | Science

Enzymes exist in ensembles of states that encode the energetics underlying their catalysis. Conformational ensembles built from 1231 structures of 17 serine proteases revealed atomic-level changes across their reaction states. By comparing the enzymatic ...

Feb 13, 2025 - 20:41
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Conformational ensembles reveal the origins of serine protease catalysis | Science
Enzymes exist in ensembles of states that encode the energetics underlying their catalysis. Conformational ensembles built from 1231 structures of 17 serine proteases revealed atomic-level changes across their reaction states. By comparing the enzymatic ...