Combinatorial screening uncovers molecules that enhance antibiotics against resistant bacteria
Researchers have created a pipeline for discovering unique combinations of molecules that increase the effectiveness of antibiotics against drug-resistant bacteria. The team, led by scientists at the Broad Institute and the Tufts University School of Medicine, used a microfluidic approach to screen more than 1 million combinations of antibiotics, small molecules, and bacteria. They identified a small molecule that boosts the power of the antibiotic rifampin in certain bacteria by weakening their defenses. The team also developed another molecule that was even more potent.
Researchers have created a pipeline for discovering unique combinations of molecules that increase the effectiveness of antibiotics against drug-resistant bacteria. The team, led by scientists at the Broad Institute and the Tufts University School of Medicine, used a microfluidic approach to screen more than 1 million combinations of antibiotics, small molecules, and bacteria. They identified a small molecule that boosts the power of the antibiotic rifampin in certain bacteria by weakening their defenses. The team also developed another molecule that was even more potent.
