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Chromosome end protection by RAP1-mediated inhibition of DNA-PK
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08896-1Biochemical, structural and genetic analysis of the shelterin complex reveal that by recruiting RAP1 to DNA, TRF2 directly inhibits DNA-dependent protein kinase to regulate classical non-homologous end joining at telomeres.
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08896-1Biochemical, structural and genetic analysis of the shelterin complex reveal that by recruiting RAP1 to DNA, TRF2 directly inhibits DNA-dependent protein kinase to regulate classical non-homologous end joining at telomeres.
