Chanoclavine synthase operates by an NADPH-independent superoxide mechanism
Nature, Published online: 05 March 2025; doi:10.1038/s41586-025-08670-3The unique structure and mechanism of chanoclavine synthase (EasC), a haem catalase that uses superoxide for substrate transformation in ergot alkaloid biosynthesis, are revealed in this study, challenging established catalase mechanisms.
Nature, Published online: 05 March 2025; doi:10.1038/s41586-025-08670-3The unique structure and mechanism of chanoclavine synthase (EasC), a haem catalase that uses superoxide for substrate transformation in ergot alkaloid biosynthesis, are revealed in this study, challenging established catalase mechanisms.
