Allosteric modulation and biased signalling at free fatty acid receptor 2
Nature, Published online: 18 June 2025; doi:10.1038/s41586-025-09186-6Structural, pharmacological and computational studies reveal how different classes of positive allosteric modulators bind to distinct allosteric sites and use noncanonical mechanisms to activate the free-fatty acid receptor FFA2.
Nature, Published online: 18 June 2025; doi:10.1038/s41586-025-09186-6Structural, pharmacological and computational studies reveal how different classes of positive allosteric modulators bind to distinct allosteric sites and use noncanonical mechanisms to activate the free-fatty acid receptor FFA2.
