A cryptic pocket in CB1 drives peripheral and functional selectivity
Nature, Published online: 05 March 2025; doi:10.1038/s41586-025-08618-7A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance, potentially revolutionizing chronic pain treatment and GPCR drug design.
Nature, Published online: 05 March 2025; doi:10.1038/s41586-025-08618-7A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance, potentially revolutionizing chronic pain treatment and GPCR drug design.
