Molecular glue unexpectedly mimics the effect of cancer mutations

Nature, Published online: 18 February 2025; doi:10.1038/d41586-025-00090-7Many conventional small-molecule drugs work by inhibiting proteins, affecting their function. One small molecule instead imbues a protein with a new function in a mechanism that could inform rational drug design.

Feb 18, 2025 - 13:09
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Molecular glue unexpectedly mimics the effect of cancer mutations

Nature, Published online: 18 February 2025; doi:10.1038/d41586-025-00090-7Many conventional small-molecule drugs work by inhibiting proteins, affecting their function. One small molecule instead imbues a protein with a new function in a mechanism that could inform rational drug design.