Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1
Nature, Published online: 23 April 2025; doi:10.1038/s41586-025-08938-8ADP-heptose binds to ALPK1, triggering transcriptional reprogramming and NF-κB activation, endowing pre-leukaemic cells with a competitive advantage due to excessive clonal proliferation.
Nature, Published online: 23 April 2025; doi:10.1038/s41586-025-08938-8ADP-heptose binds to ALPK1, triggering transcriptional reprogramming and NF-κB activation, endowing pre-leukaemic cells with a competitive advantage due to excessive clonal proliferation.
