How the fight-or-flight response resets on a molecular level

Being cut off in traffic, giving a presentation or missing a meal can all trigger a suite of physiological changes that allow the body to react swiftly to stress or starvation. Critical to this "fight-or-flight" or stress response is a molecular cycle that results in the activation of protein kinase A (PKA), a protein involved in everything from metabolism to memory formation. Now, a study by researchers at Penn State has revealed how this cycle resets between stressful events, so the body is prepared to take on new challenges.

May 28, 2025 - 20:32
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Being cut off in traffic, giving a presentation or missing a meal can all trigger a suite of physiological changes that allow the body to react swiftly to stress or starvation. Critical to this "fight-or-flight" or stress response is a molecular cycle that results in the activation of protein kinase A (PKA), a protein involved in everything from metabolism to memory formation. Now, a study by researchers at Penn State has revealed how this cycle resets between stressful events, so the body is prepared to take on new challenges.