SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08509-3Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted cancers and microsatellite-unstable cancers harbouring specific mutations.
Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08509-3Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted cancers and microsatellite-unstable cancers harbouring specific mutations.
