Regulated somatic hypermutation enhances antibody affinity maturation
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08728-2Germinal centre B cells modify their mutation rate to preserve high-affinity receptors, thereby safeguarding high-affinity B cell lineages and enhancing the outcomes of antibody affinity maturation.
Nature, Published online: 19 March 2025; doi:10.1038/s41586-025-08728-2Germinal centre B cells modify their mutation rate to preserve high-affinity receptors, thereby safeguarding high-affinity B cell lineages and enhancing the outcomes of antibody affinity maturation.
