AI still struggles with proteins: Lessons from a shape-shifting blood protein

A study by researchers at the Interuniversity Institute of Bioinformatics in Brussels, the Structural Biology research group at Vrije Universiteit Brussel, and IBiTech–BioMMedA Group of Ghent University reveals how a key blood protein involved in inflammation and cancer—alpha-1-acid glycoprotein (AGP)—behaves in complex and surprising ways. The findings illustrate the limits of even the most powerful AI tools in understanding these dynamic biological processes.

May 26, 2025 - 20:42
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A study by researchers at the Interuniversity Institute of Bioinformatics in Brussels, the Structural Biology research group at Vrije Universiteit Brussel, and IBiTech–BioMMedA Group of Ghent University reveals how a key blood protein involved in inflammation and cancer—alpha-1-acid glycoprotein (AGP)—behaves in complex and surprising ways. The findings illustrate the limits of even the most powerful AI tools in understanding these dynamic biological processes.